Hydrochloric Acid → HCID 67357934, compound

HRID 1666022Notes

Reaction equation

HRID 1666022 reaction equation
C([N:8]1[CH2:12][C@@H:11]([C:13]([N:15]2[CH2:19][C@@H:18]([N:20]([CH:28]3[CH2:33][CH2:32][C:31]([CH3:35])([CH3:34])[CH2:30][CH2:29]3)[C:21]([C@@H:23]3[CH2:27][CH2:26][CH2:25][O:24]3)=[O:22])[CH2:17][C@H:16]2[C:36]([N:38]2[CH2:43][CH2:42][N:41]([CH3:44])[CH2:40][CH2:39]2)=[O:37])=[O:14])[C@H:10]([C:45]2[CH:50]=[CH:49][C:48]([Cl:51])=[CH:47][CH:46]=2)[CH2:9]1)(OC(C)(C)C)=O.Cl>C(Cl)Cl>[Cl:51][C:48]1[CH:47]=[CH:46][C:45]([C@@H:10]2[CH2:9][NH:8][CH2:12][C@H:11]2[C:13]([N:15]2[C@H:16]([C:36]([N:38]3[CH2:39][CH2:40][N:41]([CH3:44])[CH2:42][CH2:43]3)=[O:37])[CH2:17][C@H:18]([N:20]([CH:28]3[CH2:33][CH2:32][C:31]([CH3:35])([CH3:34])[CH2:30][CH2:29]3)[C:21]([C@@H:23]3[CH2:27][CH2:26][CH2:25][O:24]3)=[O:22])[CH2:19]2)=[O:14])=[CH:50][CH:49]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67358977HCID 67358977, compound

Product 1

HCID 67357934HCID 67357934, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-BOC-(3R,4S)-3-(4-chlorophenyl)-4-({(2S,4S)-4-{(4,4-dimethylcyclohexyl)[(2S)-tetrahydrofuran-2-ylcarbonyl]amino}-2-[(4-methylpiperazin-1-yl)carbonyl]pyrrolidin-1-yl}carbonyl)pyrrolidine (1.33 g, 1.83 mmol) obtained in Step A was dissolved in DCM (1 mL) and 4 M HCl (1 mL) was added dropwise thereto. The reaction solution was stirred for 1 hour at room temperature and concentrated in vacuo to give the title compound (1.14 g, 99.8%).

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-68e8b8bff53e43b3bb781d61f4de3f47
Source dataset
uspto-grants-2011_10
Patent number
US08039622B2

Reaction notes

Loading…