Bromine → HCID 10137827, compound

HRID 1666082Notes

Reaction equation

HRID 1666082 reaction equation
[CH3:1][C:2]([CH3:26])([CH3:25])[CH2:3][NH:4][C:5]1[N:10]=[C:9]([NH:11][CH3:12])[N:8]=[C:7]([NH:13][C:14]2[CH:15]=[C:16]([CH:21]=[CH:22][C:23]=2[CH3:24])[C:17]([NH:19][CH3:20])=[O:18])[CH:6]=1.C(=O)(O)[O-].[Na+].[Br:32]Br>C(Cl)Cl>[Br:32][C:6]1[C:7]([NH:13][C:14]2[CH:15]=[C:16]([CH:21]=[CH:22][C:23]=2[CH3:24])[C:17]([NH:19][CH3:20])=[O:18])=[N:8][C:9]([NH:11][CH3:12])=[N:10][C:5]=1[NH:4][CH2:3][C:2]([CH3:26])([CH3:25])[CH3:1]

Participants

5

Reactant 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 58928526HCID 58928526, compound

Product 1

HCID 10137827HCID 10137827, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-[6-(2,2-Dimethyl-propylamino)-2-methylamino-pyrimidin-4-ylamino]-4,N-dimethyl-benzamide (35 mg), aq. sat. sodium bicarbonate (0.05 mL) and bromine (21 mg) were stirred in methylene chloride (1 mL) at room temperature for overnight. The product (4 mg) was purified with preparative thin layer chromatography. MS (m/z): 435 (M+H).

Workup

  1. customThe product (4 mg) was purified with preparative thin layer chromatography

Sources & evidence

ORD record
ord-47e2ea1f5eeb4ba4b8f585ab71085516
Source dataset
uspto-grants-2011_10
Patent number
US08044040B2

Reaction notes

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