Carbonic acid, bis(1,1-dimethylethyl) ester → HCID 12189552, compound

HRID 1666209Notes

Reaction equation

HRID 1666209 reaction equation
[CH2:1]([CH:8]1[C:13](=O)[N:12]([CH3:15])[CH2:11][C:10](=O)[NH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:23](=O)([O:29]C(C)(C)C)[O:24][C:25]([CH3:28])([CH3:27])[CH3:26]>C1COCC1>[CH2:1]([CH:8]1[CH2:13][N:12]([CH3:15])[CH2:11][CH2:10][N:9]1[C:23]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 10219638Carbonic acid, bis(1,1-dimethylethyl) esterHCID 15175833HCID 15175833, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 12189552HCID 12189552, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The compound obtained in Step (ii) was subjected to reduction with lithium aluminum hydride in THF. Then, the resultant was subjected to Boc-introducing reaction with di-tert-butyl carbonate to give the subtitle compound.

Workup

  1. additionintroducing

Sources & evidence

ORD record
ord-9d9b8ce6807f44dfbbc024f9aa6f9fe5
Source dataset
uspto-grants-2011_10
Patent number
US08044056B2

Reaction notes

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