Potassium Iodide → HCID 67445820, compound

HRID 1666210Notes

Reaction equation

HRID 1666210 reaction equation
[CH2:1]([CH:8]1[CH2:13][N:12]([CH3:14])[CH2:11][CH2:10][N:9]1[C:15](OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.BrC[CH2:24][CH2:25][N:26]1[C:34]([O:35]C)=[N:33][C:32]2[C:27]1=[N:28][C:29]([O:38][CH2:39][CH2:40][CH2:41][CH3:42])=[N:30][C:31]=2[NH2:37].[I-].[K+].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:1]([CH:8]1[CH2:13][N:12]([CH3:14])[CH2:11][CH2:10][N:9]1[CH:15]([CH2:8][CH2:1][CH2:2][CH3:3])[CH2:24][CH2:25][N:26]1[C:34](=[O:35])[NH:33][C:32]2[C:27]1=[N:28][C:29]([O:38][CH2:39][CH2:40][CH2:41][CH3:42])=[N:30][C:31]=2[NH2:37])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 12189552HCID 12189552, compoundHCID 231584909-(3-Bromopropyl)-2-butoxy-8-methoxy-9H-purin-6-amine

Product 1

HCID 67445820HCID 67445820, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The compound obtained in Step (iii) was reacted with the compound obtained in Example 1, Step (i) in the presence of potassium iodide (166 mg, 1 mmol) and potassium carbonate (207 mg, 1.5 mmol) in DMF to give the title compound.

Sources & evidence

ORD record
ord-d510c8c9525b427f884a5f3b4c7ad602
Source dataset
uspto-grants-2011_10
Patent number
US08044056B2

Reaction notes

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