Dimethylformamide → 4-(7-Azaindol-5-yloxy)-7-methoxy-6-(3-(4-methylsulphonylpiperazin-1-yl)propoxy)quinazoline
Reaction equation
[CH3:55][S:56](=[O:57])(=[O:58])[N:59]1[CH2:60][CH2:61][N:62]([CH2:65][CH2:66][CH2:67][OH:68])[CH2:63][CH2:64]1.[O:1]=[C:2]([O:3][CH2:4][CH3:5])[N:6]=[N:7][C:8]([O:9][CH2:10][CH3:11])=[O:12].[O:69]=[CH:70][N:71]([CH3:72])[CH3:73].[c:36]1([P:37]([c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[cH:50][cH:51][cH:52][cH:53][cH:54]1.[nH:13]1[cH:14][cH:15][c:16]2[cH:17][c:18]([O:22][c:23]3[n:24][cH:25][n:26][c:27]4[cH:28][c:29]([O:34][CH3:35])[c:30]([OH:33])[cH:31][c:32]34)[cH:19][n:20][c:21]12>>[nH:13]1[cH:14][cH:15][c:16]2[cH:17][c:18]([O:22][c:23]3[n:24][cH:25][n:26][c:27]4[cH:28][c:29]([O:34][CH3:35])[c:30]([O:33][CH2:67][CH2:66][CH2:65][N:62]5[CH2:61][CH2:60][N:59]([S:56]([CH3:55])(=[O:57])=[O:58])[CH2:64][CH2:63]5)[cH:31][c:32]34)[cH:19][n:20][c:21]12Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-a05588f3fb974c4c80261413363a4d98
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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