Hydrochloric Acid → HCID 66876955, compound

HRID 1666497Notes

Reaction equation

HRID 1666497 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]3[CH:27]=[C:26]([CH3:28])[CH:25]=[CH:24][N:23]=3)[CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:29].O1CCOCC1>C(Cl)Cl>[ClH:29].[CH3:28][C:26]1[CH:25]=[CH:24][N:23]=[C:22]([O:21][C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([CH:14]=[C:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[CH:16]=2)[CH:27]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66876063HCID 66876063, compound

Product 1

HCID 66876955HCID 66876955, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-[3-(4-Methyl-pyridin-2-yloxy)-benzylidene]-piperidine-1-carboxylic acid tert-butyl ester (1.15 g, 2.9 mmol) from Step 4 was dissolved in DCM (10 mL) and treated with HCl in dioxane (4.34 mL, 4.0 M, 17.3 mmol). After 16 hours the reaction was concentrated in vacuo to provide the title compound as a white solid (1.6 g).

Workup

  1. concentrationAfter 16 hours the reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-abc435c45b194a79803b7d8eacc422f5
Source dataset
uspto-grants-2011_10
Patent number
US08044052B2

Reaction notes

Loading…