Trifluoroacetic acid → HCID 66876197, compound

HRID 1666518Notes

Reaction equation

HRID 1666518 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][N:23]=3)[CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32]>ClCCl>[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32].[F:28][C:25]1[CH:26]=[CH:27][C:22]([O:21][C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([CH:14]=[C:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:16]=2)=[N:23][CH:24]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66875433HCID 66875433, compound

Product 1

HCID 66876197HCID 66876197, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl-4-(3-(5-fluoropyridin-2-yloxy)benzylidene)piperidine-1-carboxylate (0.274 g) in dichloromethane (2.5 mL, 0.28 M) was treated with trifluoroacetic acid (2.5 mL). The reaction was allowed to stir for 3 hours, then concentrated to an oil. The oil was used without purification. 0.466 g, quantitative yield.

Workup

  1. concentrationconcentrated to an oil
  2. customThe oil was used without purification

Sources & evidence

ORD record
ord-c6a68c454f9e45e79521cb248d5453c9
Source dataset
uspto-grants-2011_10
Patent number
US08044052B2

Reaction notes

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