反应详情

温度

120 °C

2-(2-Aminoanilino)-5-methylthiophene-3-carbonitrile (2.0 g) is taken in N-methyl-piperazine (12 ml) and acetic acid (2 ml). The solution is heated at 120° C. until completion of reaction. The reaction mass is cooled and tetrahydrofuran is added. The reaction mixture is stirred for 30 minutes. The water is added at 45-50° C., the mixture is cooled up to room temperature and the solid is precipitated out. The solid is filtered off and washed with tetrahydrofuran-water mixture.

1. temperatureThe reaction mass is cooled
2. temperaturethe mixture is cooled up to room temperature
3. customthe solid is precipitated out
4. filtrationThe solid is filtered off
5. washwashed with tetrahydrofuran-water mixture