Hydrochloric Acid → HCID 67358282, compound

HRID 1667106Notes

Reaction equation

HRID 1667106 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([CH:9]([N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[CH3:10])[CH:6]=[CH:7][CH:8]=1.[ClH:26].C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>CO>[ClH:26].[ClH:26].[F:25][C:2]([F:1])([F:24])[C:3]1[CH:4]=[C:5]([CH:9]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH3:10])[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 67445097HCID 67445097, compound

Product 1

HCID 67358282HCID 67358282, compoundYield 129.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product from Example 44A (0.071 g, 0.198 mmol) was added to HCl (2.0 Min dioxane) (0.991 mL, 1.981 mmol), and methanol was added dropwise until the reaction became nearly homogeneous. As the reaction was stirred, a precipitate formed. The reaction was concentrated to give the title compound (0.066 g, 0.256 mmol) as the dihydrochloride salt. MS (APCI) m/z 259 (M+H)+.

Workup

  1. additionwas added dropwise until the reaction
  2. customa precipitate formed
  3. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-0c4518a0a0044e6489fbde671b271bba
Source dataset
uspto-grants-2011_10
Patent number
US08044069B2

Reaction notes

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