Hydrochloric Acid → HCID 67358827, compound

HRID 1667220Notes

Reaction equation

HRID 1667220 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[CH2:6][N:7]1[CH2:10][CH:9]([NH:11]C(=O)OC(C)(C)C)[CH2:8]1.[ClH:24]>CO.O1CCOCC1>[ClH:24].[F:22][C:2]([F:1])([F:23])[C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[CH2:6][N:7]1[CH2:8][CH:9]([NH2:11])[CH2:10]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67445744tert-Butyl [1-[[3-(trifluoromethyl)phenyl]methyl]azetidin-3-yl]carbamate

Product 1

HCID 67358827HCID 67358827, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of product from Example 180A (0.14 g) in methanol (5 mL) was added 4 N HCl in dioxane (1 mL), and the mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated to yield the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 8.81 (bs, 2H), 7.95 (m, 1H), 7.84 (m, 2H), 7.71 (t, J=7.73 Hz, 1H), 4.63 (s, 2H), 4.23 (m, 5H); MS (DCI) m/z 231 (M+H)+.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-ae37ba5314be4eadbe9925ac54e0fcd3
Source dataset
uspto-grants-2011_10
Patent number
US08044069B2

Reaction notes

Loading…