Hydrochloric Acid → HCID 178524141, compound

HRID 1667397Notes

Reaction equation

HRID 1667397 reaction equation
[CH:1]1[C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]2[C:10](O[C:13](=[O:14])[C:3]=2[CH:2]=1)=[O:11].[NH2:15][NH2:16].Cl>C(O)(C)C>[OH:14][C:13]1[C:3]2[C:4](=[CH:5][C:6]([C:7]([OH:9])=[O:8])=[CH:1][CH:2]=2)[C:10]([OH:11])=[N:16][N:15]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 9321HydrazineHCID 11089Trimellitic anhydride

Product 1

HCID 178524141HCID 178524141, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 1,2,4 benzenetricarboxylic anhydride (5 g, 0.026 mol) and anhydrous hydrazine (1.67 g, 0.052 mol) in isopropyl alcohol (50 mL) was refluxed for 5 hours. The resulting mixture was neutralized with concentrated HCl and stirred at room temperature for an additional 1 hour. The mixture was filtered and the white residue washed with isopropyl alcohol to provide 1,4-dihydroxy-phthalazine-6-carboxylic acid (5.1 g, 95%) as a white solid.

Workup

  1. temperaturewas refluxed for 5 hours
  2. filtrationThe mixture was filtered
  3. washthe white residue washed with isopropyl alcohol

Sources & evidence

ORD record
ord-1313c43522ed4933bfe783943a03f341
Source dataset
uspto-grants-2011_10
Patent number
US08044041B2

Reaction notes

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