反应详情

A mixture of 6-Bromo-2H-phthalazin-1-one (2.5 g), phosphorous oxychloride (11 mL) and diisopropyl ethyl amine (2 mL) was stirred at RT for 30 min then at 90° C. for 3 h. The reaction was then concentrated under reduced pressure, diluted with ethyl acetate and washed with a saturated solution of NaHCO3, NH4Cl, and brine to afford the desired compound (2.0 g). TLC Rf 0.8 (EA/hexane 2/3).

1. waitat 90° C. for 3 h
2. concentrationThe reaction was then concentrated under reduced pressure
3. additiondiluted with ethyl acetate
4. washwashed with a saturated solution of NaHCO3, NH4Cl, and brine