Hydrochloric Acid → (3-Aminomethyl-phenyl)-(2-morpholin-4-yl-ethyl)-amine hydrochloride

HRID 1667497Notes

Reaction equation

HRID 1667497 reaction equation
C(OC(=O)[NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([NH:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH:9]=1)(C)C.[ClH:24]>CO>[ClH:24].[NH2:6][CH2:7][C:8]1[CH:9]=[C:10]([NH:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67415913[3-(2-Morpholin-4-yl-ethylamino)-benzyl]-carbamic acid isopropyl ester

Product 1

HCID 67416818(3-Aminomethyl-phenyl)-(2-morpholin-4-yl-ethyl)-amine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of [3-(2-morpholin-4-yl-ethylamino)-benzyl]-carbamic acid isopropyl ester (200 mg, 0.596 mmol), methanol (4 mL) and 4.89N isopropanolic hydrochloric acid (2.4 mL) was stirred at room temperature overnight. The reaction was concentrated and dried to yield (3-aminomethyl-phenyl)-(2-morpholin-4-yl-ethyl)-amine hydrochloride (212 mg) as an orange solid. m/z (M+1) 236.04.

Workup

  1. concentrationThe reaction was concentrated
  2. customdried

Sources & evidence

ORD record
ord-d0461efb317140da8943833de944b134
Source dataset
uspto-grants-2011_10
Patent number
US08044041B2

Reaction notes

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