HCID 67444123, compound → HCID 57448187, compound

HRID 1667594Notes

Reaction equation

HRID 1667594 reaction equation
FC(F)(F)C(O)=O.[NH2:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:19][CH:20]([C:31]3[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[C:33]([O:39][CH3:40])[CH:32]=3)[C:21]([O:23]CC3C=CC=CC=3)=[O:22])=[CH:16][CH:17]=2)[CH:12]=[CH:11][N:10]=1>C1COCC1.[Pd]>[NH2:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:19][CH:20]([C:31]3[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[C:33]([O:39][CH3:40])[CH:32]=3)[C:21]([OH:23])=[O:22])=[CH:16][CH:17]=2)[CH:12]=[CH:11][N:10]=1

Participants

4

Reactant 1

HCID 67444123HCID 67444123, compound

Product 1

HCID 57448187HCID 57448187, compoundYield 110%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

6F (130 mg, 0.29 mmol) was dissolved in THF (8 mL). To this solution was added 10% Pd/C (cat.), and the mixture was hydrogenated at 50 psi for 16 h. The reaction was filtered and concentrated to provide 6G (113 mg, 10%). LC-MS: 355.19 (M+H)+.

Workup

  1. filtrationThe reaction was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-c273d2cbc2a142a7858d75cc81f15fbe
Source dataset
uspto-grants-2011_10
Patent number
US08044242B2

Reaction notes

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