Indoline → 1-(4-{(S)-1-[(R)-1-(4-Methoxy-phenyl)-ethyl]-pyrrolidin-2-yl}-pyridin-2-yl)-2,3-dihydro-1H-indole

HRID 1667617Notes

Reaction equation

HRID 1667617 reaction equation
Br[C:2]1[CH:7]=[C:6]([C@@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C@@H:13]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH3:14])[CH:5]=[CH:4][N:3]=1.[NH:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:25][CH2:24]1.C1(P(C2CCCCC2)C2C=CC=CC=2C2C=CC=CC=2)CCCCC1.CC(C)([O-])C.[K+]>C1(C)C=CC=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].CCOC(C)=O.O>[CH3:22][O:21][C:18]1[CH:19]=[CH:20][C:15]([C@H:13]([N:9]2[CH2:10][CH2:11][CH2:12][C@H:8]2[C:6]2[CH:5]=[CH:4][N:3]=[C:2]([N:23]3[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH2:25][CH2:24]3)[CH:7]=2)[CH3:14])=[CH:16][CH:17]=1

Participants

9

Reactant 4

HCID 10328IndolineHCID 27342162-(Dicyclohexylphosphino)biphenylHCID 23665647Potassium tert-butoxideHCID 581118522-Bromo-4-{(S)-1-[(R)-1-(4-methoxy-phenyl)-ethyl]-pyrrolidin-2-yl}-pyridine

Product 1

HCID 581119481-(4-{(S)-1-[(R)-1-(4-Methoxy-phenyl)-ethyl]-pyrrolidin-2-yl}-pyridin-2-yl)-2,3-dihydro-1H-indoleYield 85.5%

Reagents, catalysts & solvents 4

HCID 9811564Bis(dibenzylideneacetone)palladiumCatalystHCID 962WaterSolventHCID 1140TolueneSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
85 °C

Procedure

To a solution of 2-Bromo-4-{(S)-1-[(R)-1-(4-methoxy-phenyl)-ethyl]-pyrrolidin-2-yl}-pyridine (0.15 g, 0.41 mmol) in toluene (30 mL) are added indoline (0.10 g, 0.83 mmol), 2-(dicyclohexylphosphino)-biphenyl (14 mg, 0.04 mmol), Pd2(dba)3 (19 mg, 0.02 mmol) and potassium tert-butoxide (0.11 g, 1.04 mmol). The reaction mixture is stirred at 85° C. for 3 h and cooled to room temperature. Water and EtOAc are added to the mixture. The layers are separated and the aqueous layer is extracted with EtOAc. The combined organic layers are washed with brine, dried over Na2SO4, filtered and concentrated down. The crude product is purified by flash chromatography on silica gel (EtOAc/Hexane: 5%˜25%) to give (1-(4-{(S)-1-[(R)-1-(4-Methoxy-phenyl)-ethyl]-pyrrolidin-2-yl}-pyridin-2-yl)-2,3-dihydro-1H-indole (140 mg, 84%) as an oil. M/Z=400.2 [M+1]

Workup

  1. temperaturecooled to room temperature
  2. customThe layers are separated
  3. extractionthe aqueous layer is extracted with EtOAc
  4. washThe combined organic layers are washed with brine
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated down
  8. customThe crude product is purified by flash chromatography on silica gel (EtOAc/Hexane: 5%˜25%)

Sources & evidence

ORD record
ord-68c2fcf38305444eb4251c21e1cec851
Source dataset
uspto-grants-2011_10
Patent number
US08044209B2

Reaction notes

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