反应详情

To a solution of methyl 3-(1-cyano-1-methylethyl)benzoate (2.8 g, 14 mmol) in tetrahydrofuran (30 mL) were added lithium hydroxide-monohydrate (0.98 g, 24 mmol), methanol (10 mL) and water (10 mL), and the mixture was stirred at room temperature for 18 hr. The solvent was evaporated under reduced pressure, and the residue was diluted with water (15 mL). The mixture was adjusted to pH 3 by slowly adding 1N hydrochloric acid. The precipitated white precipitate was collected by filtration, washed with water, and air-dried to give the title compound (2.5 g, 98%) as a white powder.

1. customThe solvent was evaporated under reduced pressure
2. additionthe residue was diluted with water (15 mL)
3. additionby slowly adding 1N hydrochloric acid
4. filtrationThe precipitated white precipitate was collected by filtration
5. washwashed with water
6. customair-dried