Triethylamine → HCID 57505508, compound

HRID 1667936Notes

Reaction equation

HRID 1667936 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][CH:26]=1)[O:5][C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([NH:15][C:16]([CH:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[O:17])[N:14]=2)[N:11]=1.C(N(CC)CC)C.[CH3:34][N:35]1[C:39]([C:40](Cl)=[O:41])=[CH:38][C:37]([CH3:43])=[N:36]1>O1CCCC1>[CH3:34][N:35]1[C:39]([C:40]([NH:1][C:2]2[CH:26]=[CH:25][CH:24]=[C:4]([O:5][C:6]3[CH:7]=[CH:8][C:9]4[N:10]([CH:12]=[C:13]([NH:15][C:16]([CH:18]5[CH2:19][CH2:20][O:21][CH2:22][CH2:23]5)=[O:17])[N:14]=4)[N:11]=3)[CH:3]=2)=[O:41])=[CH:38][C:37]([CH3:43])=[N:36]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 27362992,5-Dimethyl-2H-pyrazole-3-carbonyl chlorideHCID 57505440HCID 57505440, compound

Product 1

HCID 57505508HCID 57505508, compoundYield 27%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Using N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]tetrahydro-2H-pyran-4-carboxamide (200 mg, 0.57 mmol), triethylamine (237 mL, 1.70 mmol), 1,3-dimethyl-1H-pyrazole-5-carbonyl chloride (180 mg, 1.13 mmol) and tetrahydrofuran (6.0 mL) as starting materials and in the same manner as in Example 96, the title compound (73 mg, 27%) was obtained as a white powder.

Sources & evidence

ORD record
ord-5c82e23273c6409786e1646c775e9ca3
Source dataset
uspto-grants-2011_10
Patent number
US08044049B2

Reaction notes

Loading…