Ammonia → tert-Butyl 4-amino-4-cyanopiperidine-1-carboxylate

HRID 166814Notes

Reaction equation

HRID 166814 reaction equation
[C-:16]#[N:17].[CH3:21][OH:22].[Cl-:19].[NH3:15].[NH4+:20].[Na+:18].[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[C:2]1([NH2:20])([C:21]#[N:15])[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

8

Reactant 7

HCID 222AmmoniaHCID 223AmmoniumHCID 312ChlorideHCID 887MethanolHCID 923Sodium ionHCID 5975CyanideHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 22091429tert-Butyl 4-amino-4-cyanopiperidine-1-carboxylate

Sources & evidence

ORD record
ord-8dadb7ee09844e60aef48b7bc2897c3c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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