Diisopropylethylamine → HCID 24946567, compound

HRID 1668282Notes

Reaction equation

HRID 1668282 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][CH:10]([NH:16][C:17]([NH:19][CH2:20][CH2:21]O)=[S:18])[C:11]2[O:12][CH:13]=[CH:14][CH:15]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.C(N(C(C)C)CC)(C)C.[I-].C(C[P+](C)(C)C)#N>C(#N)CC>[S:18]1[CH2:21][CH2:20][N:19]=[C:17]1[NH:16][CH:10]([C:11]1[O:12][CH:13]=[CH:14][CH:15]=1)[CH2:9][C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH3:8])[CH:5]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 10514344(Cyanomethyl)trimethylphosphanium iodideHCID 24946392HCID 24946392, compound

Product 1

HCID 24946567HCID 24946567, compoundYield 69.1%

Reagents, catalysts & solvents 1

HCID 7854PropionitrileSolvent

Conditions

Temperature
90 °C

Procedure

Following the procedure as described in example a solution of 1-[2-(3,5-dimethylphenyl)-1-furan-2-yl-ethyl]-3-(2-hydroxy-ethyl)-thiourea (0.46 g) and diisopropyethylamine (0.26 g) in propionitrile (20 ml) was treated with cyanomethyl trimethylphosphonium iodide (0.44 g) and heated for 16 h at a temperature of 90° C. Work-up yielded the title compound (0.30 g, 69%) as an amorphous solid.

Sources & evidence

ORD record
ord-4a3f3eb29cb9434ab7a79c73b63f651a
Source dataset
uspto-grants-2011_08
Patent number
US07989394B2

Reaction notes

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