Diethyl Ether → HCID 67360334, compound

HRID 1668355Notes

Reaction equation

HRID 1668355 reaction equation
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[Br:9][C:10]1[C:25]([F:26])=[CH:24][C:13]2[O:14][C:15]3[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:16]=3[CH:17]=[N:18][C:12]=2[CH:11]=1.C(OCC)C>C1(C)C(C)=CC=CC=1>[Br:9][C:10]1[C:25]([F:26])=[CH:24][C:13]2[O:14][C:15]3[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:16]=3[C@H:17]3[C@H:2]([C:1]([OH:7])=[O:8])[CH2:3][CH2:4][C:5](=[O:6])[N:18]3[C:12]=2[CH:11]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 7940Glutaric anhydrideHCID 67358580HCID 67358580, compound

Product 1

HCID 67360334HCID 67360334, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Conditions

Temperature
150 °C

Procedure

Glutaric anhydride (7.93 g, 69.5 mmol) was added to a stirred solution of 8-bromo-3,7-difluoro-dibenz[b,f][1,4]oxazepine (14.4 g, 46.4 mmol) in xylene (30 mL) and the mixture was heated to 150° C. for 72 h. The reaction mixture was allowed to cool to ambient temperature, and diethyl ether was added. The product was collected by filtration and dried to yield the title compound which was used without further purification (16.2, 82%).

Workup

  1. temperatureto cool to ambient temperature
  2. filtrationThe product was collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-990ff14220c34236b9435ab3ed7ce25a
Source dataset
uspto-grants-2011_08
Patent number
US07989442B2

Reaction notes

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