Glutaric anhydride → HCID 67358906, compound

HRID 1668361Notes

Reaction equation

HRID 1668361 reaction equation
[Br:1][C:2]1[C:17]([F:18])=[CH:16][C:5]2[O:6][C:7]3[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:8]=3[CH:9]=[N:10][C:4]=2[CH:3]=1.[C:19]1(=[O:26])[O:25][C:23](=[O:24])[CH2:22][CH2:21][CH2:20]1>C(OCC)(=O)C>[Br:1][C:2]1[C:17]([F:18])=[CH:16][C:5]2[O:6][C:7]3[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:8]=3[C@H:9]3[C@H:22]([C:23]([OH:25])=[O:24])[CH2:21][CH2:20][C:19](=[O:26])[N:10]3[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 7940Glutaric anhydrideHCID 67358021HCID 67358021, compound

Product 1

HCID 67358906HCID 67358906, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Preparation analogous to Example 5, step e, from 8-bromo-1,7-difluorodibenz[b,f][1,4]oxazepine (8 g, 25.8 mmol) and glutaric anhydride (5.9 g, 51.6 mmol). After cooling down, the reaction mixture was dissolved in ethyl acetate, washed with water, dried (Na2SO4) and evaporated to afford the title carboxylic acid (10.9 g, 100%)

Workup

  1. customPreparation analogous to Example 5, step e
  2. temperatureAfter cooling down
  3. washwashed with water
  4. dry with materialdried (Na2SO4)
  5. customevaporated

Sources & evidence

ORD record
ord-a777f031626041ca82e27c091909e004
Source dataset
uspto-grants-2011_08
Patent number
US07989442B2

Reaction notes

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