Ethanol → HCID 67360824, compound

HRID 1668382Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([C:13]([O:15]C)=O)=[C:10]([N:17]=[CH:18][N:19]([CH3:21])C)[CH:9]=2)=[CH:4][CH:3]=1.[C:22]([O:26][C:27]([N:29]([CH2:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38]CN)=[CH:34][CH:33]=1)[CH3:30])=[O:28])([CH3:25])([CH3:24])[CH3:23].C(O)C>C(OCC)(=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:12][C:11]3[C:13](=[O:15])[N:19]([CH2:21][CH2:38][C:35]4[CH:36]=[CH:37][C:32]([CH2:31][N:29]([CH3:30])[C:27](=[O:28])[O:26][C:22]([CH3:25])([CH3:23])[CH3:24])=[CH:33][CH:34]=4)[CH:18]=[N:17][C:10]=3[CH:9]=2)=[CH:6][CH:7]=1

Participants

Conditions

Temperature: 70 °C

Procedure

A mixture of methyl 5-(4-chlorophenyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylate (0.2 g), 2-[4-(N-tert-butyloxycarbonyl-N-methylaminomethyl)phenyl]ethanamine (0.19 g) and ethanol (4 ml) were stirred at 70° C. for 3 hr. The reaction mixture was allowed to cool, ethyl acetate was added, and the precipitate was collected by filtration to give the title compound (160 mg) as a colorless powder.

Workup

temperatureto cool
filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record: ord-979bc0fb3ea54745969745e54c623247
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07989445B2

Reaction notes

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