反应详情

AllylGlyOH (10.5 g, 26.4 mmol) is suspended in dichloromethane (200 mL) and EDCI (5.1 g, 26.4 mmol) and DMAP (3.2 g, 26.4 mmol) are added to obtain a clear solution. 11E homoallylproline amide in dichloromethane (50 mL) is added and stirred overnight. The product is quenched with saturated bicarb and extracted with dichloromethane, followed by washing with brine, drying over anhydrous magnesium sulfate, filtering and concentrating. The crude is used in following deprotection. LCMS characterization ES+456.1 (m+1).

1. customto obtain a clear solution
2. customThe product is quenched with saturated bicarb
3. extractionextracted with dichloromethane
4. washby washing with brine
5. dry with materialdrying over anhydrous magnesium sulfate
6. filtrationfiltering
7. concentrationconcentrating