反应详情

Boc-N-MeAlaOH (5.36 g, 26.4 mmol) is suspended in dichloromethane (200 mL) and EDCI (5.4 g, 28 mmol) and DMAP (3.4 g, 28 mmol) are added to obtain a clear solution. 11G in dichloromethane (50 mL) is added and stirred overnight followed by quenching with saturated bicarb and extracting with dichloromethane then washing with brine, drying over anhydrous magnesium sulfate, filtering and concentrating. LCMS characterization ES+541.2 (m+1).

1. customto obtain a clear solution
2. customby quenching with saturated bicarb
3. extractionextracting with dichloromethane
4. washthen washing with brine
5. dry with materialdrying over anhydrous magnesium sulfate
6. filtrationfiltering
7. concentrationconcentrating