Hydrogen Bromide → HCID 67359067, compound

HRID 1668590Notes

Reaction equation

HRID 1668590 reaction equation
Cl.C[O:3][C:4]1[CH:14]=[CH:13][C:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12][C:6]=2[C:5]=1[CH3:15].[BrH:16]>>[BrH:16].[OH:3][C:4]1[CH:14]=[CH:13][C:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12][C:6]=2[C:5]=1[CH3:15]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 67359454HCID 67359454, compound

Product 1

HCID 67359067HCID 67359067, compound

Procedure

7-Methoxy-6-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride (8.6 g) was treated with 48% HBr (100 ml) at 110° C. for 4 hours; volatiles were evaporated under reduced pressure obtaining crude 7-hydroxy-6-methyl-1,2,4,5-tetrahydro-3H-3-benzazepine hydrobromide (10.2 g).

Workup

  1. customvolatiles were evaporated under reduced pressure

Sources & evidence

ORD record
ord-9a2420a9088c4799bbc0cba224b66622
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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