Ethanol → HCID 57825009, compound

HRID 1668743Notes

Reaction equation

HRID 1668743 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8](F)[CH:9]=1)[C:5]#[N:6].C[Si]([N-][Si](C)(C)C)(C)C.[Na+].[CH2:21]([OH:23])[CH3:22]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:23][CH2:21][CH3:22])[CH:9]=1)[C:5]#[N:6]

Participants

4

Reactant 3

HCID 702EthanolHCID 2724254Sodium bis(trimethylsilyl)amideHCID 27833303-Bromo-5-fluorobenzonitrile

Product 1

HCID 57825009HCID 57825009, compoundYield 44%

Procedure

In analogy to the procedure described in WO2007060448, the reaction of 3-bromo-5-fluorobenzonitrile with ethanol using sodium bis(trimethylsilyl)amide as the base yielded the title compound as a light brown oil (yield: 44% of theory).

Sources & evidence

ORD record
ord-f353914028b74196adb91a967c5e4f17
Source dataset
uspto-grants-2011_08
Patent number
US07989449B2

Reaction notes

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