Methyl iodide → HCID 57825114, compound

HRID 1668751Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][OH:11])[CH:5]=[C:6]([Br:8])[CH:7]=1.I[CH3:13].[H-].[Na+]>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][O:11][CH3:13])[CH:5]=[C:6]([Br:8])[CH:7]=1

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 24758Sodium hydride

HCID 19048532HCID 19048532, compound

Product 1

HCID 57825114HCID 57825114, compoundYield 86%

Procedure

In analogy to the procedure described for Building Block AW, the alkylation of 2-(3,5-dibromo-phenyl)-ethanol with iodomethane using sodium hydride as the base yielded the title compound 86% yield as a light yellow oil.

Sources & evidence

ORD record: ord-91eb8c64fa804e969008394faa25e362
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07989449B2

Reaction notes

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