Methylamine → (2-Methylamino-quinazolin-4-yl)-(4-dimethylaminophenyl)-methylamine

HRID 1668783Notes

Reaction equation

HRID 1668783 reaction equation
Cl[C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:19]=[CH:18][C:17]([N:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=2)[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:23][NH2:24]>>[CH3:23][NH:24][C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:19]=[CH:18][C:17]([N:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=2)[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 11688214(2-Chloro-quinazolin-4-yl)-(4-dimethylaminophenyl)-methylamine

Product 1

HCID 11638105(2-Methylamino-quinazolin-4-yl)-(4-dimethylaminophenyl)-methylamine

Procedure

The title compound was prepared from (2-chloro-quinazolin-4-yl)-(4-dimethylaminophenyl)-methylamine and methyl amine by a procedure similar to example 14. 1H NMR (CDCl3): 7.42-7.42 (m, 1H), 7.34 (ddd, J=8.1, 6.9, 4.0, 1H), 7.04 (m, 2H), 6.94 (m, 1H), 6.63-6.71 (m, 3H), 5.13 (s, broad, 1H), 3.49 (s, 3H), 3.10 (d, J=4.8, 3H), 2.97 (s, 6H).

Sources & evidence

ORD record
ord-808f4526e0fb46b8b67e9ff6fd6d180e
Source dataset
uspto-grants-2011_08
Patent number
US07989462B2

Reaction notes

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