Methylamine → (2-Methylamino-6-nitroquinazolin-4-yl)-(4-methoxyphenyl)-methylamine

HRID 1668785Notes

Reaction equation

HRID 1668785 reaction equation
Cl[C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:22]([O-:24])=[O:23])[CH:8]=2)[N:3]=1.[CH3:25][NH2:26]>>[CH3:25][NH:26][C:2]1[N:11]=[C:10]([N:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:22]([O-:24])=[O:23])[CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 11609884(2-Chloro-6-nitroquinazolin-4-yl)-(4-methoxyphenyl)-methylamine

Product 1

HCID 11595263(2-Methylamino-6-nitroquinazolin-4-yl)-(4-methoxyphenyl)-methylamine

Procedure

The title compound was prepared from (2-chloro-6-nitro-quinazolin-4-yl)-(4-methoxyphenyl)-methylamine and methyl amine by a procedure similar to example 14. 1H NMR (CDCl3): 8.11 (dd, J=9.3, 8.0, 1H), 7.73 (d, J=2.4, 1H), 7.33 (m, 1H), 7.15 (m, 2H), 6.98 (m, 2H), 5.29 (s, broad, 1H), 3.86 (s, 3H), 3.55 (s, broad, 3H), 3.14 (d, J=4.8, 3H).

Sources & evidence

ORD record
ord-60f7507c09a84955a0a0c11af6c6ba35
Source dataset
uspto-grants-2011_08
Patent number
US07989462B2

Reaction notes

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