Methyl iodide → HCID 59648371, compound

HRID 1668802Notes

Reaction equation

HRID 1668802 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[CH:14][N:13]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH3:22]I.[H-].[Na+]>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:11]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[CH:14][N:13]=2)[CH3:22])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 16805556HCID 16805556, compound

Product 1

HCID 59648371HCID 59648371, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared from (3,4-dimethoxy-phenyl)-quinazolin-4-yl-amine (130 mg, 0.46 mmol), methyl iodide (0.043 ml, 0.7 mmol), sodium hydride (28 mg, 0.7 mmol, 60% oil dispersion) in DMF similar to example 21 to give 2.0 mg (2%) of white solids. 1H NMR (CDCl3): 7.88 (s, 1H), 7.55-7.45 (m, 2H), 7.31 (d, J=7.2 Hz, 1H), 6.97 (t, J=7.2 Hz, 1H), 6.86 (d, J=8.4 Hz, 1H), 6.45 (d, J=2.1 Hz, 1H), 6.37 (d, J=2.4 Hz, J=8.1 Hz, 1H), 3.91 (s, 3H), 3.82 (s, 3H), 3.53 (s, 3H).

Sources & evidence

ORD record
ord-7b57dcb3e46a480681da3a01e76f1249
Source dataset
uspto-grants-2011_08
Patent number
US07989462B2

Reaction notes

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