Hydrochloric Acid → HCID 86627901, compound

HRID 1669439Notes

Reaction equation

HRID 1669439 reaction equation
[CH2:1]([N:8]([C@@H:19]1[CH2:26][N:25]2[C:27]3[CH:28]=[C:29]([C:40]([NH:42][S:43]([N:46]([CH2:48][CH:49](OC)[O:50]C)[CH3:47])(=[O:45])=[O:44])=[O:41])[CH:30]=[CH:31][C:32]=3[C:33]([CH:34]3[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]3)=[C:24]2[C:23]2[CH:54]=[CH:55][C:56]([F:58])=[CH:57][C:22]=2[O:21][CH2:20]1)[CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C1COCC1>[NH2:11][CH2:10][CH2:9][N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C@@H:19]1[CH2:26][N:25]2[C:27]3[CH:28]=[C:29]([C:40]([NH:42][S:43]([N:46]([CH3:47])[CH2:48][CH:49]=[O:50])(=[O:45])=[O:44])=[O:41])[CH:30]=[CH:31][C:32]=3[C:33]([CH:34]3[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]3)=[C:24]2[C:23]2[CH:54]=[CH:55][C:56]([F:58])=[CH:57][C:22]=2[O:21][CH2:20]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86761383HCID 86761383, compound

Product 1

HCID 86627901HCID 86627901, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

Tert-butyl [2-(benzyl{(7R)-14-cyclohexyl-11-[({[(2,2-dimethoxyethyl)(methyl)amino]sulfonyl}amino)carbonyl]-3-fluoro-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocin-7-yl}amino)ethyl]carbamate was dissolved in THF (50 mM) and 3M aqueous HCl (10 eq) was added. The solution was warmed to 60° C. and stirred for 2 h. The solution was then used directly in the next step. (ES+) m/z 676 (M+H)+.

Sources & evidence

ORD record
ord-00bd8bfcc6024444811db6ba734358e1
Source dataset
uspto-grants-2011_08
Patent number
US07989438B2

Reaction notes

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