Trifluoroacetic acid → HCID 67344786, compound

HRID 1669459Notes

Reaction equation

HRID 1669459 reaction equation
C(OC([NH:8][S:9]([N:12]([CH3:50])[CH:13]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][N:20]([CH3:49])[C@@H:21]2[CH2:28][N:27]3[C:29]4[CH:30]=[C:31]([C:42]([OH:44])=[O:43])[CH:32]=[CH:33][C:34]=4[C:35]([CH:36]4[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]4)=[C:26]3[C:25]3[CH:45]=[CH:46][CH:47]=[CH:48][C:24]=3[O:23][CH2:22]2)[CH2:14]1)(=[O:11])=[O:10])=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][S:9]([N:12]([CH3:50])[CH:13]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][N:20]([CH3:49])[C@@H:21]2[CH2:28][N:27]3[C:29]4[CH:30]=[C:31]([C:42]([OH:44])=[O:43])[CH:32]=[CH:33][C:34]=4[C:35]([CH:36]4[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]4)=[C:26]3[C:25]3[CH:45]=[CH:46][CH:47]=[CH:48][C:24]=3[O:23][CH2:22]2)[CH2:14]1)(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67345302HCID 67345302, compound

Product 1

HCID 67344786HCID 67344786, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (7R)-7-[(2-{3-[{[(tert-butoxycarbonyl)amino]sulfonyl}(methyl)amino]pyrrolidin-1-yl}ethyl)(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid in DCM was treated with TFA and the solution was left stirring for 1 h. All volatiles were removed in vacuo to leave the product as pale yellow foam. (ES+) m/z 610 (M+H)+.

Workup

  1. waitthe solution was left
  2. customAll volatiles were removed in vacuo

Sources & evidence

ORD record
ord-11204653d5954c02b52d97663b792e9c
Source dataset
uspto-grants-2011_08
Patent number
US07989438B2

Reaction notes

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