Hydrochloric Acid → HCID 23729141, compound

HRID 1669504Notes

Reaction equation

HRID 1669504 reaction equation
C(OC([NH:8][C@@H:9]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[CH:23][CH:22]=2)=[CH:16][CH:15]=1)[C:10]([OH:12])=[O:11])=O)(C)(C)C.[ClH:34]>O1CCOCC1>[ClH:34].[NH2:8][C@@H:9]([CH2:13][C:14]1[CH:15]=[CH:16][C:17]([O:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[CH:23][CH:22]=2)=[CH:18][CH:19]=1)[C:10]([OH:12])=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67350875HCID 67350875, compound

Product 1

HCID 23729141HCID 23729141, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To the carboxylic acid from step 2 (65 mg) was added 4.0 M HCl in dioxane (1.0 mL). After 3 h, the dioxane was removed to give 58 mg of product. 1H NMR (400 MHz, DMSO-d6) δ 3.11-3.28 (m, 2H), 4.20 (t, J=6.0 Hz, 1H), 6.94-7.15 (m, 9H), 7.27-7.32 (m, 2H), 7.36-7.42 (m, 2H); LCMS; 99%, ESI−, Calcd: 349.39 m/z. Found 348.5 (M−1) m/z.

Workup

  1. customthe dioxane was removed

Sources & evidence

ORD record
ord-646ff201127c4856a2b6fa52923cabc7
Source dataset
uspto-grants-2011_08
Patent number
US07989480B2

Reaction notes

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