Lactide, L- → HCID 131729080, compound

HRID 1669631Notes

Reaction equation

HRID 1669631 reaction equation
[CH3:1][C@@H:2]1[O:9]C(=O)[C@H](C)[O:5][C:3]1=[O:4].[CH2:11]([O:18][C:19]([NH:21][CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[C:31](=[O:32])[O:30]CC(=O)[NH:27]1)=[O:20])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(Cl)(Cl)Cl>[C:3]([OH:5])(=[O:4])[CH2:2][OH:9].[CH2:11]([O:18][C:19]([NH:21][CH2:22][CH2:23][CH2:24][CH2:25][C@@H:26]([C:31]([OH:32])=[O:30])[NH2:27])=[O:20])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1.[C:3]([OH:5])(=[O:4])[C@H:2]([CH3:1])[OH:9]

Participants

4

Reactant 2

HCID 107983Lactide, L-2×HCID 91595355HCID 91595355, compound2×

Product 1

HCID 131729080HCID 131729080, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

According to the molar ratio of L-Lactide: 3-[4-(benzyloxycarbonylamino) butyl]-morpholine-2,5-dione monomer=1: 19, 42.75 g L-Lactide and 5 g 3-[4-(benzyloxycarbonylamino) butyl]-morpholine-2,5-dione monomer are weighed and put into ampule, and then inject 5 ml stannous octoate chloroform solution of 30 mg/ml. After volatilization of the chloroform under vacuum, the ampule is sealed with alcohol blast burner. Finally, the sealed ampule is put into oil-bath of 90-140° C. for 12-72 h to obtain poly (glycolic acid-Nε-benzyloxycarbonyl-L-lysine-L-lactic acid).

Sources & evidence

ORD record
ord-4ee20dff3c204618af249d337aae3426
Source dataset
uspto-grants-2011_08
Patent number
US07989532B2

Reaction notes

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