CAS 33135-50-1 Lactide, L- (HCID 107983)

Overview

Lactide, L- is under investigation in clinical trial NCT05450471 (Effectiveness of Endonasal Polymeric Implant for Chronic Rhinosinusitis).

Names & identifiers

Preferred name: Lactide, L-
IUPAC: (3S,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione
English name: L-Lactide
Molecular formula: C6H8O4
Molecular weight: 144.13

Names & synonyms

L-Lactide4511-42-6L-(-)-LactideL,L-DilactideLactide, L-(-)-L-DilactidePurasorb LLL-Lactide(3S-cis)-3,6-Dimethyl-1,4-dioxane-2,5-dioneUNII-IJ13TO4NO1IJ13TO4NO1EINECS 224-832-0

Show more names

LACTIDEL-LAL-(-)-DILACTIDE(3S)-CIS-3,6-DIMETHYL-1,4-DIOXANE-2,5-DIONEactide-(-)-L(3S,6S)

EC 224-832-01,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3S-cis)-P-DIOXANE-2,5-DIONE, 3,6-DIMETHYL-, L-1,4-DIOXANE-2,5-DIONE, 3,6-DIMETHYL-, (3S,5S)-RefChem:7658224-832-0(3S,6S)-3,6-dimethyl-1,4-dioxane-2,5-dioneL-Dilactide

Database identifiers

CAS: 33135-50-1、4511-42-6
PubChem CID: 107983
DTXSID: DTXSID5049655
UNII: IJ13TO4NO1
EC Number: 224-832-0
Nikkaji: J150.826A

Properties

Computed structural properties

XLogP: 0.6
Topological polar surface area: 52.6 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 4
Rotatable bonds: 0
Heavy atoms: 10
Formal charge: 0
Complexity: 155

Physicochemical properties

Melting point: 92 · 92-94 °C(lit.)
Boiling point: 255 °C · 255°C
Density: 1.186 · 1.186±0.06 g/cm3(Predicted)
vapor pressure: 0.311 Pa · 0.311Pa at 25℃
refractive index: 1.4475 · 1.4475
storage temp.: 2 · 2-8°C
solubility: Soluble in chloroform, and methanol. Slightly soluble in benzene.
form: Solid
color: White to Off-White
optical activity: 20 · [α]20/D 285°, c = 1 in toluene
Water Solubility: 16.7 g/L · 16.7g/L at 20℃
Sensitive: Moisture Sensitive
BRN: 82124 · 82124
Stability: Hygroscopic
InChI: 1S/C6H8O4/c1-3-5(7)10-4(2)6(8)9-3/h3-4H,1-2H3/t3-,4-/m0/s1
InChIKey: JJTUDXZGHPGLLC-IMJSIDKUSA-N
SMILES: C[C@@H]1OC(=O)[C@H](C)OC1=O
LogP: 0.4 at · 0.4 at 25℃
CAS DataBase Reference: 4511 · 4511-42-6(CAS DataBase Reference)
FDA UNII: 13 TO4NO1 · IJ13TO4NO1
EPA Substance Registry System: 1 · 1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3S,6S)- (4511-42-6)
UNSPSC Code: 12352005 · 12352005
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 319 · H319
Precautionary statements: 305 · P305+P351+P338
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38-36
Safety Statements: 26 · 26-37/39
WGK Germany: 3 · 3
TSCA: TSCA listed
HS Code: 29322090 · 29322090
Storage Class: 13 · 13 - Non Combustible Solids
Hazard Classifications: 2 · Eye Irrit. 2
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H314 (10.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P321, P337+P317, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 183 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 2 items

PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Status: Active Update: 01-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/11212

Hazard Classes and CategoriesSkin Corr. 1B (10.9%)

Safety data

PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 3
tsca: TSCA listed
hs_code: 29322090
risk_code: 36/37/38-36
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
safety_code: 26-37/39
Storage Class: 13 - Non Combustible Solids
Hazard statements: H319
REACH Registrations: Active
Hazard Classifications: Eye Irrit. 2
Precautionary statements: P305+P351+P338

Chemistry & industry

Uses & manufacturing

General Manufacturing Information1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3S,6S)-: ACTIVE

Applications · 2 items

DescriptionL-lactide (3,6-dimethyl-1,4-dioxane-2,5-dione) is a cyclic lactone that is derived from lactic acid. It has the molecular formula C3H6O2 and is an essential building block for synthesizing polylactic acid (PLA) plastics, which are widely used in the manufacturing industry.

Uses(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione may be used in the synthesis of optically active terpyridine containing poly(L-lactide)s, polydisperse lactic acid oligomers, bicyclic and tricyclic lactide derivatives.