Hydrochloric Acid → HCID 59166737, compound

HRID 1669670Notes

Reaction equation

HRID 1669670 reaction equation
Cl.[O:2]=[C:3]1[C:11]2([CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:20]C(=O)OC(C)(C)C)[CH:17]=3)[CH2:12]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4]1>CCOC(C)=O>[NH2:20][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[CH2:12][C:11]1([C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[NH:4][C:3]1=[O:2])[CH2:19]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86617227HCID 86617227, compound

Product 1

HCID 59166737HCID 59166737, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

HCl(g) was bubbled through a solution of (±)-tert-butyl (2′-oxo-1,1′,2′,3-tetrahydrospiro[indene-2,3′-indol]-5-yl)carbamate from Step C (19.0 mg, 0.054 mmol) in EtOAc (5 mL) for 15 min. The reaction mixture was stirred at ambient temperature for 1 h and then concentrated in vacuo to give the title compound as the hydrochloride salt. MS: m/z=251 (M+1).

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-f452e59e82364443ab274ced1dd7d8e1
Source dataset
uspto-grants-2011_08
Patent number
US07989624B2

Reaction notes

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