HCID 57438909, compound → HCID 67342657, compound

HRID 1669810Notes

Reaction equation

HRID 1669810 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[O:4][N:3]=1.[H][H]>[Pt](=O)=O.C(O)C>[NH2:3][C:2]([CH3:1])=[CH:6][C:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:14])([F:15])[F:16])=[CH:9][CH:8]=1)=[O:4]

Participants

5

Reactant 2

HCID 57438909HCID 57438909, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67342657HCID 67342657, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

3-Methyl-5-[4-(trifluoromethyl)phenyl]isoxazole (1.8 g, 7.92 mmol) is introduced into 20 ml of ethanol, platinum(IV) oxide catalyst (180 mg) is added, and the mixture is then hydrogenated under atmospheric pressure hydrogen for 12 h. The catalyst is filtered off, and the filtrate is concentrated. 1.72 g (94% of theory) of the title compound are obtained as a white solid.

Workup

  1. additionis added
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-0e0bb7eb4aa04412897715cc916dc4a4
Source dataset
uspto-grants-2011_08
Patent number
US07989633B2

Reaction notes

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