HCID 57438911, compound → HCID 67343450, compound

HRID 1669814Notes

Reaction equation

HRID 1669814 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:9][CH:8]=2)[O:4][N:3]=1.[H][H]>[Pt](=O)=O.C(O)C>[NH2:3][C:2]([CH3:1])=[CH:6][C:5]([C:7]1[CH:8]=[CH:9][C:10]([C:13]([CH3:16])([CH3:15])[CH3:14])=[CH:11][CH:12]=1)=[O:4]

Participants

5

Reactant 2

HCID 57438911HCID 57438911, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67343450HCID 67343450, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

3-Methyl-5-[4-(tert-butyl)phenyl]isoxazole (900 mg, 4.18 mmol) is introduced into 20 ml of ethanol, platinum(IV) oxide catalyst (90 mg) is added and the mixture is then hydrogenated under atmospheric pressure hydrogen for 12 h. The catalyst is filtered off and the filtrate is concentrated. 897 mg (99% of theory) of the title compound are obtained as a white solid.

Workup

  1. additionis added
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-3ce0f9780f3b43fd84b9e37f584c244c
Source dataset
uspto-grants-2011_08
Patent number
US07989633B2

Reaction notes

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