1-Methylpiperazine → (3-Iodo-5-methoxy-phenyl)-(4-methyl-piperazin-1-yl)-methanone

HRID 1670069Notes

Reaction equation

[CH2:1]([NH:8][C:9](=[O:19])[C:10]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]([I:18])[CH:11]=1)[C:2]1C=CC=CC=1.[CH3:20][N:21]1CCN[CH2:23][CH2:22]1.IC1C=C(C=C(OC)C=1)C(O)=O>>[I:18][C:12]1[CH:11]=[C:10]([C:9]([N:8]2[CH2:1][CH2:2][N:21]([CH3:20])[CH2:22][CH2:23]2)=[O:19])[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=1

Participants

Reactant 3

HCID 531671-Methylpiperazine

HCID 579057573-Iodo-5-methoxybenzoic acid

HCID 57905830N-benzyl-3-iodo-5-methoxy-benzamide

Product 1

HCID 57905823(3-Iodo-5-methoxy-phenyl)-(4-methyl-piperazin-1-yl)-methanoneYield 80%

Procedure

The title compound was prepared by the same method as N-benzyl-3-iodo-5-methoxy-benzamide. 4-Methylpiperazine was used instead of benzylamine. Starting with 3.1 g of 3-iodo-5-methoxybenzoic acid, 3.2 g (80% yield) of the title compound was obtained.

Sources & evidence

ORD record: ord-15541b4598884175b2dd85859314d68d
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07989454B2

Reaction notes

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