反应详情

3,5-Dihydrobenzoic acid methyl ester (20.2 g) was dissolved in acetone (400 mL) and then potassium carbonate (16.6 g) and benzyl bromide (20.5 g) were added. The resulting mixture was refluxed for 3 h. Then the insoluble material was filtered off and the filtrate was concentrated under reduced pressure. The residue was purified on a silica gel column using chloroform and methanol to yield 12.4 g (40% yield) of the title compound.

1. temperatureThe resulting mixture was refluxed for 3 h
2. filtrationThen the insoluble material was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue was purified on a silica gel column