反应详情

温度

55 °C

To a solution of 5-benzyloxy-3′-fluoro-biphenyl-3-carboxylic acid methyl ester (4.2 g) was added a solution of LiOH (2.9 g) in water (50 mL) and the resulting mixture was stirred at 55° C. overnight. The reaction mixture was acidified with 3 N HCl and the white precipitate was collected by filtration. It was washed with water and dried on air to yield the title compound (3.8 g, 94% yield).

1. filtrationthe white precipitate was collected by filtration
2. washIt was washed with water
3. customdried on air