Hydrochloric Acid → HCID 131727209, compound

HRID 1670222Notes

Reaction equation

HRID 1670222 reaction equation
[ClH:1].O1CCOCC1.[CH2:8]([NH:15][C:16]1[CH:21]=[C:20]([O:22][C:23]2[CH:28]=[CH:27][C:26]([NH:29]C(=O)OC(C)(C)C)=[CH:25][C:24]=2[F:37])[CH:19]=[CH:18][N:17]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[ClH:1].[NH2:29][C:26]1[CH:27]=[CH:28][C:23]([O:22][C:20]2[CH:19]=[CH:18][N:17]=[C:16]([NH:15][CH2:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:21]=2)=[C:24]([F:37])[CH:25]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59852895HCID 59852895, compound

Product 1

HCID 131727209HCID 131727209, compoundYield 100%

Procedure

Anhydrous HCl in dioxane (4N, 2.00 mL, 8.00 mmol, 165 eq) was added to tert-butyl 4-(2-(benzylamino)pyridin-4-yloxy)-3-fluorophenylcarbamate (0.020 g, 0.0489 mmol, 1.0 eq) and the reaction mixture was stirred at room temperature for 12 h. The reaction mixture was concentrated in vacuo to afford the title compound (0.017 g, 100%) a solid that was used without further purification. MS (ESI+) m/z 310 (M+H)+; HRMS (ESI+) calcd.: 310.1356. found: 310.1364.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-c1ca2a4d02ff42778f0dfccf5ac92e66
Source dataset
uspto-grants-2011_08
Patent number
US07989477B2

Reaction notes

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