反应详情

温度

50 °C

3,6-Dichloropyridazine-4-carboxylic acid (1.15 g, 5.96 mmol) and 1,1′-carbonyldiimidazole (CDI (0.97 g) in DMF (25 ml) were stirred at room temperature for 2 h. A solution of 2,3-diaminobenzamide (1.30 g, 5.96 mmol) in pyridine (25 ml) was added and the solution heated at 50° C. for 4 h. The cooled solution was concentrated and partitioned between ethyl acetate (EtOAc) and water, the organic layer separated, dried, filtered and concentrated to give the product.

1. concentrationThe cooled solution was concentrated
2. custompartitioned between ethyl acetate (EtOAc) and water
3. customthe organic layer separated
4. customdried
5. filtrationfiltered
6. concentrationconcentrated
7. customto give the product