反应详情

10 ml of TFA are added dropwise, at 0° C., to a 100 ml round-bottomed flask containing 1.0 g of 17 (4.38 mmol), 10 ml of water and 14 ml of THF. The medium is left to return to AT and stirred overnight. The medium is then concentrated at reduced pressure, at AT, and 50 ml of water are added, and the mixture is frozen and lyophilized. The lyophilizate is made into a paste in heptane, in the presence of a minimum amount of methanol, after the solvents have been evaporated off. 778 mg of expected product 18 (white solid) are obtained.

1. waitThe medium is left
2. concentrationThe medium is then concentrated at reduced pressure, at AT, and 50 ml of water
3. additionare added
4. temperaturethe mixture is frozen
5. customafter the solvents have been evaporated off