Hydrochloric Acid → HCID 67328829, compound

HRID 1670421Notes

Reaction equation

HRID 1670421 reaction equation
[CH2:1]([N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][C:11](=[O:19])[C@@H:10]([NH:20]C(=O)OC(C)(C)C)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:28]>O1CCOCC1>[ClH:28].[NH2:20][C@@H:10]1[C:11](=[O:19])[NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57617783HCID 57617783, compound

Product 1

HCID 67328829HCID 67328829, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

357.5 mg of 15 (0.97 mmol) prepared according to the procedure described in step 1 are taken up in a 25 mL round-bottomed flask and 6.3 ml of dioxane and 7.5 mL of a solution of hydrochloric acid in dioxane (4M) are added. The medium is stirred overnight at RT under argon. A precipitate forms which is drained and washed with isopropyl ether (15 mL) and dried under vacuum. 280 mg of expected product 16 (white solid) are obtained in hydrochloride form.

Workup

  1. customare taken up in a 25 mL round-bottomed flask
  2. washwashed with isopropyl ether (15 mL)
  3. customdried under vacuum

Sources & evidence

ORD record
ord-6e91281c95184209aa18496332cdba9c
Source dataset
uspto-grants-2011_08
Patent number
US07994161B2

Reaction notes

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