L-Tartaric acid → HCID 86623708, compound

HRID 1670575Notes

Reaction equation

HRID 1670575 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]2[CH2:6][CH2:7][NH:8][CH2:9][CH2:10][C:4]=2[C:3]=1[CH2:13][S:14][C:15]1[NH:16][C:17]([CH3:20])=[N:18][CH:19]=1.[C:21]([OH:30])(=[O:29])[C@@H:22]([C@H:24]([C:26]([OH:28])=[O:27])[OH:25])[OH:23]>CO.O>[C:26]([C@@H:24]([C@H:22]([C:21]([OH:30])=[O:29])[OH:23])[OH:25])([OH:28])=[O:27].[Cl:1][C:2]1[CH:12]=[CH:11][C:5]2[CH2:6][CH2:7][NH:8][CH2:9][CH2:10][C:4]=2[C:3]=1[CH2:13][S:14][C:15]1[NH:16][C:17]([CH3:20])=[N:18][CH:19]=1

Participants

5

Reactant 2

HCID 444305L-Tartaric acidHCID 59822264HCID 59822264, compound

Product 1

HCID 86623708HCID 86623708, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Dissolve 7-chloro-6-(2-methyl-3H-imidazol-4-ylthiomethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (193 mg, 0.63 mmol) in methanol (12 mL) and water (1 mL) and add L-(+)-tartaric acid (94 mg, 0.63 mmol). Stir the mixture for 1 h and concentrate the mixture in vacuo. Dissolve in water, and freeze dry the solution to provide the title compound (32 mg, 100%). MS (APCI) m/z: 308 (M+H)+.

Workup

  1. concentrationconcentrate the mixture in vacuo
  2. dissolutionDissolve in water
  3. customfreeze dry the solution

Sources & evidence

ORD record
ord-2e4a785a8dd244aab13235920b82de28
Source dataset
uspto-grants-2011_08
Patent number
US07994163B2

Reaction notes

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