Water → 1-Bromo-4-fluoro-2-(2-iodo-benzyloxy)-benzene

HRID 1670591Notes

Reaction equation

HRID 1670591 reaction equation
[I:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[Br:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=1[OH:18].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=1[O:18][CH2:4][C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[I:1]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 27246002-Bromo-5-fluorophenolHCID 114264722-Iodobenzyl Bromide

Product 1

HCID 585644251-Bromo-4-fluoro-2-(2-iodo-benzyloxy)-benzeneYield 102.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Stir a mixture of 2-iodobenzyl bromide (0.29 mol, 90 g), 2-bromo-5-fluorophenol (0.29 mol, 57.9 g), and potassium carbonate (0.46 mol, 63 g) in N,N-dimethylformamide (750 mL) at room temperature for 16 h. Add water (1 L), stir the resulting mixture for one hour, filter off solids, rinse with water and dry in a vacuum oven (20 mm Hg/60° C.) to obtain the title compound (121 g, >100%). 1H NMR (400 MHz, DMSO-d6) δ 5.11 (s, 2H), 6.81 (t, 1H), 7.13 (t, 1H), 7.19 (dd, 1H), 7.46 (t, 1H), 7.59 (d, 1H), 7.62 (t, 1H), 7.93 (d, 1H).

Workup

  1. filtrationfilter off solids
  2. washrinse with water
  3. customdry in a vacuum oven (20 mm Hg/60° C.)

Sources & evidence

ORD record
ord-da703b49da9043babf73fec4258d1a11
Source dataset
uspto-grants-2011_08
Patent number
US07994164B2

Reaction notes

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