反应详情

4-(2-Chloroethyl)morpholine hydrochloride (1.2 equiv., 0.806 mmol, 0.121 g) and potassium carbonate (3 equiv., 2.01 mmol, 0.278 g) were added to a solution compound 10 (1.0 equiv., 6.71 mmol, 0.250 g) in DMF (3 ml). The mixture was heated at reflux for 2 h. The reaction product was precipitated by the addition of water, filtered off and washed with isopropanol and isopropyl ether successively to give 9-[2-(4-morpholinyl)-ethoxy]-6-(4-nitrophenyl)-pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-one (79) (0.156 g, yield=46%, purity (LC)=95%) as a brown powder.

1. temperatureThe mixture was heated
2. temperatureat reflux for 2 h
3. customThe reaction product was precipitated by the addition of water
4. filtrationfiltered off
5. washwashed with isopropanol and isopropyl ether successively