反应详情

Bromoethylacetate (1.2 equiv., 1.128 mmol, 0.188 g) and potassium carbonate (3.0 equiv., 2.820 mmol, 0.390 g) were added to a solution of 10 (1.0 equiv., 0.940 mmol, 0.350 g) in DMF (10 ml). The mixture was heated at reflux for 2 h. The reaction product was precipitated by the addition of water, filtered off and washed with isopropanol and isopropyl ether successively to give ethyl 2-[[5,6-dihydro-6-(4-nitrophenyl)-5-oxo-pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-9-yl]oxy]-acetate (13) (0.409 g, yield=95%, purity (LC)=92%) as a light red powder.

1. temperatureThe mixture was heated
2. temperatureat reflux for 2 h
3. customThe reaction product was precipitated by the addition of water
4. filtrationfiltered off
5. washwashed with isopropanol and isopropyl ether successively