Potassium Iodide → HCID 86633608, compound

HRID 1670717Notes

Reaction equation

HRID 1670717 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Br:11])[C:9]=1[OH:10])[CH:5]=[O:6].Br[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Br:11])[C:9]=1[O:10][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=1)[CH:5]=[O:6]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 181003,5-Dibromo-4-HydroxybenzaldehydeHCID 40672073-Methoxybenzyl bromide

Product 1

HCID 86633608HCID 86633608, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 3,5-dibromo-4-hydroxybenzaldehyde (0.28 g), 1-bromomethyl-3-methoxybenzene (0.15 mL), potassium carbonate (0.29 g) and potassium iodide (42 mg) in 10 mL absolute ethanol was stirred at 80° C. for 2 days. The reaction mixture was concentrated and the title compound was obtained as a off-white solid after flash column chromatography (silica gel, heptane/ethyl acetate (3/7, v/v)), Rf=0.51).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-9f201f560d184d6b9aaa95d91b1106c8
Source dataset
uspto-grants-2011_08
Patent number
US07994189B2

Reaction notes

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